Hypoxia Enhances PDGF Signaling in the Pulmonary Vasculature…

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  • OpenAlex ID W7010315692
  • Type Article
  • Language EN
  • Source Max Planck Institute for Plasma Physics
  • Added 10 Oct 2025
  • Updated 13 Oct 2026
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Hypoxia Enhances PDGF Signaling in the Pulmonary Vasculature by Downregulation of Protein Tyrosine Phosphatases

Article EN

RATIONALE: Platelet-derived growth factor (PDGF) plays a pivotal role in the pathobiology of pulmonary hypertension (PH) as it promotes pulmonary vascular remodeling. PH is frequently associated with pulmonary hypoxia. OBJECTIVE: To investigate whether hypoxia alters PDGF beta receptor (betaPDGFR) signaling in the pulmonary vasculature. METHODS: The impact of chronic hypoxia on signal transduction…

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UN Sustainable Development Goals
1 SDGs
Authors & Affiliations
12 authors
#AuthorInstitutionsORCID
1 Ten Freyhaus, H. — —
2 Dagnell, M. — —
3 Leuchs, M. — —
4 Vantler, M. — —
5 Eva Maria Berghausen —
6 Caglayan, E. — —
7 Weissmann, N. — —
8 Dahal, B. K. — —
9 Schermuly, R. T. — —
10 Ostman, A. — —
11 Kappert, K. — —
12 Rosenkranz, S. — —

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