Abstract 5774: Hypoxia Enhances Platelet-derived Growth Fact…

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  • DOI 10.1161/circ.120.suppl_18.s1146
  • OpenAlex ID W4395042932
  • Type Conference-abstract
  • Language EN
  • Published 03 Nov 2009
  • Volume 120 (suppl_18)
  • Source Circulation
  • Publisher Lippincott Williams & Wilkins
  • Countries 2
  • Institutions 4
  • Added 24 Apr 2024
  • Updated 22 Oct 2026
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Abstract 5774: Hypoxia Enhances Platelet-derived Growth Factor Signaling in the Pulmonary Vasculature by HIF-1 α -dependent Downregulation of Protein Tyrosine Phosphatases

Conference-abstract 2009 EN

Background: Platelet-derived growth factor (PDGF) plays a critical role in the development of pulmonary hypertension (PH) as it promotes pulmonary vascular remodeling. PH is frequently associated with severe pulmonary hypoxia. Here we investigated whether hypoxia alters PDGF β receptor ( β PDGFR) signaling. Methods and Results: Chronic hypoxia enhanced PDGF-BB-dependent proliferation and chemotaxi…

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UN Sustainable Development Goals
1 SDGs
Authors & Affiliations
11 authors
#AuthorInstitutionsORCID
1 Henrik ten Freyhaus University of Cologne (DE)
2 Maike Leuchs University of Cologne (DE) —
3 Markus Dagnell Karolinska Institutet (SE)
4 Marius Vantler University of Cologne (DE)
5 Evren Caglayan University of Cologne (DE)
6 Norbert Weißmann Justus-Liebig-Universität Gieß… (DE)
7 RALPH THEO SCHERMULY Justus-Liebig-Universität Gieß… (DE)
8 Bhola Kumar Dahal Justus-Liebig-Universität Gieß… (DE) —
9 Arne Östman Karolinska Institutet (SE)
10 Kappert Kai Charité – Universitätsmedizin … (DE) —
11 Stephan Rosenkranz University of Cologne (DE)
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