Hypoxia- or PDGF-BB-dependent paxillin tyrosine phosphorylat…

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  • DOI 10.1160/th13-12-1031
  • PMID https://pubmed.ncbi.nlm.nih.gov/25231004
  • OpenAlex ID W1999750324
  • Type Article
  • Language EN
  • Published 01 Jan 2014
  • Volume 112 (12)
  • Pages 1288–1303
  • Source Thrombosis and Haemostasis
  • Publisher Thieme Medical Publishers (Germany)
  • FWCI 1.33
  • Countries 2
  • Institutions 4
  • Added 24 Jun 2016
  • Updated 31 Oct 2026
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Hypoxia- or PDGF-BB-dependent paxillin tyrosine phosphorylation in pulmonary hypertension is reversed by HIF-1α depletion or imatinib treatment

Article 2014 EN

Chronic exposure to hypoxia induces a pronounced remodelling of the pulmonary vasculature leading to pulmonary hypertension (PH). The remodelling process also entails increased proliferation and decreased apoptosis of pulmonary arterial smooth muscle cells (PASMC), processes regulated by the cytoskeletal protein paxillin. In this study, we aimed to examine the molecular mechanisms leading to dereg…

21

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43

References

10

Authors

1.33

FWCI

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10 authors
#AuthorInstitutionsORCID
1 Christine Veith German Center for Lung Researc… (DE) Universities of Giessen and Ma… (DE)
2 Dariusz Zakrzewicz Justus-Liebig-Universität Gieß… (DE) German Center for Lung Researc… (DE)
3 Bhola Kumar Dahal German Center for Lung Researc… (DE) Universities of Giessen and Ma… (DE) —
4 Zoltán Bálint Ludwig Boltzmann Institute for… (AT)
5 Kirsten Murmann German Center for Lung Researc… (DE) Universities of Giessen and Ma… (DE)
6 Małgorzata Wygrecka Justus-Liebig-Universität Gieß… (DE) German Center for Lung Researc… (DE)
7 Werner Seeger German Center for Lung Researc… (DE) Universities of Giessen and Ma… (DE)
8 RALPH THEO SCHERMULY German Center for Lung Researc… (DE) Universities of Giessen and Ma… (DE)
9 Grażyna Kwapiszewska Justus-Liebig-Universität Gieß… (DE) Ludwig Boltzmann Institute for… (AT)
10 Norbert Weißmann Corresponding Justus-Liebig-Universität Gieß… (DE)
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