Single-cell analysis of immune recognition in chronic myeloi…
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- DOI 10.1038/s41375-023-02074-w
- PMID https://pubmed.ncbi.nlm.nih.gov/37919606
- PMCID https://www.ncbi.nlm.nih.gov/pmc/articles/10776410
- OpenAlex ID W4388212582
- Type Article
- Language EN
- Published 02 Nov 2023
- Volume 38 (1)
- Pages 109–125
- Source Leukemia
- Publisher Springer Nature
- FWCI 5.35
- Countries 4
- Institutions 12
- Added 03 Nov 2023
- Updated 31 Oct 2026
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Single-cell analysis of immune recognition in chronic myeloid leukemia patients following tyrosine kinase inhibitor discontinuation
Article 2023 EN Hybrid
Abstract Immunological control of residual leukemia cells is thought to occur in patients with chronic myeloid leukemia (CML) that maintain treatment-free remission (TFR) following tyrosine kinase inhibitor (TKI) discontinuation. To study this, we analyzed 55 single-cell RNA and T cell receptor (TCR) sequenced samples (scRNA+TCRαβ-seq) from patients with CML (n = 13, N = 25), other cancers (n = 28…
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21 authors| # | Author | Institutions | ORCID |
|---|---|---|---|
| 1 | Jani Huuhtanen Corresponding | University of Helsinki (FI) Helsinki University Hospital (FI) +1 | |
| 2 | Shady Adnan Awad | University of Helsinki (FI) Helsinki University Hospital (FI) +1 | |
| 3 | Jason Theodoropoulos | University of Helsinki (FI) Helsinki University Hospital (FI) | |
| 4 | Sofia Forstén | University of Helsinki (FI) Helsinki University Hospital (FI) | |
| 5 | Rebecca Warfvinge | Lund University (SE) | — |
| 6 | Olli Dufva | University of Helsinki (FI) Helsinki University Hospital (FI) | |
| 7 | Jonas Bouhlal | University of Helsinki (FI) Helsinki University Hospital (FI) | |
| 8 | Parashar Dhapola | Lund University (SE) | |
| 9 | Hanna Duàn | University of Helsinki (FI) Helsinki University Hospital (FI) | |
| 10 | Essi Laajala | University of Helsinki (FI) Helsinki University Hospital (FI) | |
| 11 | Tiina Kasanen | University of Helsinki (FI) Helsinki University Hospital (FI) | |
| 12 | Jay Klievink | University of Helsinki (FI) Helsinki University Hospital (FI) | |
| 13 | Mette Matilda Ilander | University of Helsinki (FI) Helsinki University Hospital (FI) | |
| 14 | Taina Jaatinen | Finnish Red Cross (FI) | |
| 15 | Ulla Olsson‐Strömberg | Uppsala University (SE) Uppsala University Hospital (SE) | — |
| 16 | Henrik Hjorth‐Hansen | Norwegian University of Scienc… (NO) St Olav's University Hospital (NO) | |
| 17 | Andreas Burchert | Philipps University of Marburg (DE) Universitätsklinikum Gießen un… (DE) | |
| 18 | Göran Karlsson | Lund University (SE) | |
| 19 | Anna S. Kreutzman | University of Helsinki (FI) Helsinki University Hospital (FI) | |
| 20 | Harri J Lähdesmäki | Aalto University (FI) | |
| 21 | Satu M. Mustjoki Corresponding | University of Helsinki (FI) Helsinki University Hospital (FI) |
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