IMMUNE MATURATION AND CHECKPOINT DYNAMICS DURING TYROSINE KINASE INHIBITOR DOSE REDUCTION PREDICT RELAPSE RISK IN PATIENTS WITH CHRONIC MYELOID LEUKEMIA UNDERGOING TREATMENT DISCONTINUATION

In Chronic Myeloid Leukemia (CML), patients who achieve sustained deep molecular response (DMR) to Tyrosine Kinase Inhibitors (TKIs) are eligible for treatment discontinuation, but only 50% of these patients maintain long-term treatment-free remission (TFR). Biomarkers that predict TFR loss (TFRL) of the molecular response after TKI interruption have not been defined to date. We hypothesized that…