Activated Memory Cytotoxic T-Lymphocytes and T-Cell Receptor…

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Activated Memory Cytotoxic T-Lymphocytes and T-Cell Receptor Vβ Clonality Predict Treatment-Free Remission After Tyrosine Kinase Inhibitor Discontinuation in Chronic-Phase Chronic Myeloid Leukemia: A 1-Year Prospective Immuno-Monitoring Study

Article 2026 EN Gold

We prospectively evaluated whether cytotoxic T-lymphocyte (CTL) activation and T-cell receptor (TCR) Vβ clonality predict treatment-free remission (TFR) after tyrosine kinase inhibitor (TKI) cessation in chronic-phase chronic myeloid leukemia (CML). Forty-five patients with sustained deep molecular response (DMR) were enrolled (On-TKI, n = 38; Off-TKI, n = 7) and underwent one-year immuno-monitori…

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10

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34.33

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10 authors
#AuthorInstitutionsORCID
1 Tatsuro Jo Corresponding Japanese Red Cross Nagasaki Ge… (JP)
2 Yoshio Saburi Oita Prefectural Hospital (JP)
3 Taro Masunari Chugoku Central Hospital (JP)
4 Kazuhiro Noguchi Japanese Red Cross Nagasaki Ge… (JP) —
5 Takahiro Sakai Japanese Red Cross Nagasaki Ge… (JP)
6 Jun Taguchi Japanese Red Cross Nagasaki Ge… (JP)
7 Eiichi Ohtsuka Oita Prefectural Hospital (JP)
8 Nobuo Sezaki Chugoku Central Hospital (JP)
9 Ritsuko Kubota‐Koketsu Center for Infectious Disease … (JP) The University of Osaka (JP)
10 Toru Kiguchi Chugoku Central Hospital (JP) Dokkyo Medical University Sait… (JP) +2

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