A Simple Sequential Incubation Method for Deconvoluting the Complicated Sequential Metabolism of Capravirine in Humans

Capravirine undergoes extensive oxygenation in humans. Since several pathways may be involved in the formation and/or sequential metabolism of a single metabolite, it is impossible to determine the definitive pathways and their relative contributions to the overall metabolism of capravirine using conventional approaches. For this reason, a human liver microsome‐based sequential incubation method h…