Prostacyclin mimetics with non-prostanoid structures

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1995
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  • DOI 10.1254/fpj.106.181
  • PMID https://pubmed.ncbi.nlm.nih.gov/8529963
  • OpenAlex ID W2055553905
  • Type Article
  • Language EN
  • Published 01 Jan 1995
  • Volume 106 (3)
  • Pages 181–190
  • Source Folia Pharmacologica Japonica
  • Publisher Japanese Pharmacological Society
  • FWCI 0.29
  • Countries 1
  • Institutions 1
  • Added 10 Oct 2025
  • Updated 21 Aug 2026
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Prostacyclin mimetics with non-prostanoid structures

Article 1995 EN Bronze

In searching for new drugs, we have developed receptor binding assays for prostanoids. Among the various compounds that we have tested, we have found that hydronaphthalene derivatives can interact with some prostanoid receptors. Modification of such compounds produced several pure prostacyclin agonists (ONO-AP-227 and ONO-AP-437) and a unique prostacyclin agonist with inhibitory activity against t…

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1 Kigen Kondo Ono Pharmaceutical (Japan) (JP) —
2 Nobuyuki Hamanaka — —
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