Nicotinic Cholinergic Regulation of Tyrosine Hydroxylase Gen…

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Nicotinic Cholinergic Regulation of Tyrosine Hydroxylase Gene Expression and Catecholamine Synthesis in Isolated Bovine Adrenal Chromaffin Cells

Article 1992 EN

Isolated bovine adrenal chromaffin cells were used to study the nicotinic regulation of tyrosine hydroxylase (TH) gene expression. Continuous exposure of the cells to carbachol or the nicotinic receptor agonist 1,1-dimethyl-4-phenylpiperazinium (DMPP) produces a time- and concentration-dependent increase in TH enzyme activity, whereas muscarine has no effect. DMPP at 1 microM (EC50 = 0.3 microM) e…

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1 Gale L. Craviso Corresponding The University of Texas Health… (US)
2 Virginia B. Hemelt — —
3 Jack C. Waymire — —

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