Nicotine increases expression of tyrosine hydroxylase gene. …
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- DOI 10.1016/s0021-9258(19)49518-5
- PMID https://pubmed.ncbi.nlm.nih.gov/7901211
- OpenAlex ID W1523374635
- Type Article
- Language EN
- Published 01 Nov 1993
- Volume 268 (31)
- Pages 23704–23711
- Source Journal of Biological Chemistry
- Publisher Elsevier BV
- FWCI 1.29
- Countries 1
- Institutions 1
- Added 24 Jun 2016
- Updated 30 Oct 2026
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Nicotine increases expression of tyrosine hydroxylase gene. Involvement of protein kinase A-mediated pathway.
Article 1993 EN Hybrid
Nicotine, a major component of tobacco smoke, stimulates catecholamine secretion and activates catecholamine biosynthetic enzymes such as tyrosine hydroxylase (TH) and dopamine beta-hydroxylase (DBH) in adrenal medullary cells. We investigated the effect of long term treatment with nicotine on TH and DBH gene expression in rat PC12 pheochromocytoma cells. Nicotine treatment for 1-2 days increased…
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1.29
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1 SDGsAuthors & Affiliations
5 authors| # | Author | Institutions | ORCID |
|---|---|---|---|
| 1 | Bhargava Hiremagalur | New York Medical College (US) | — |
| 2 | Bistra B. Nankova | New York Medical College (US) | |
| 3 | J Nitahara | New York Medical College (US) | — |
| 4 | Richard J. Zeman | New York Medical College (US) | — |
| 5 | Esther Louise Sabban | New York Medical College (US) |
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