Pretreatment effect of adenosine on activation of NF—κB and level of TNF—α during myocardial ischemia and reperfusion in rats

Objective: To study the pretreatment effect of adenosine on NF-κB nuclear activity in ischemia/reperfusion myocardium in rats. Methods: Eighteen healthy male S-D rats were randomly divided into three groups. Group I was the control group. The other two groups were subjected to 30 minutes of ischemia, followed by 2 hours of reperfusion. In group III, adenosine was given 40 μg*kg-1*min-1 30 minutes…