Mapping hemagglutinin residues driving antigenic diversity i…

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Mapping hemagglutinin residues driving antigenic diversity in H5Nx avian influenza viruses

Article 2026 EN Diamond

ABSTRACT Since its emergence in 1996, the H5 avian influenza virus (AIV) A/Goose/Guangdong/1/1996 (Gs/GD) hemagglutinin (HA) has evolved into over 30 genetically and antigenically distinct clades, including the widespread clade 2.3.4.4b. Vaccination is widely used in endemic regions to reduce poultry losses and zoonotic risk. However, the evolving antigenic diversity and global co-circulation of m…

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4 authors
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1 Rebecca Daines The Pirbright Institute (GB) Royal Veterinary College (GB)
2 Jean-Rémy Sadeyen The Pirbright Institute (GB)
3 Pengxiang Chang The Pirbright Institute (GB)
4 Munir Iqbal Corresponding The Pirbright Institute (GB)

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