Mitochondrial DNA Sensing in Type I Interferon Responses and Disease

Mitochondria are pleiotropic organelles central to a wide array of cellular pathways including metabolism, signal transduction, and programmed cell death. Mitochondria also play key roles in mammalian immune responses, functioning as scaffolds for innate immune signaling, governing metabolic switches required for immune cell activation, and releasing agonists that promote inflammation. Due to thei…