Defining how mitochondrial DNA stress regulates innate immun…

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  • DOI 10.4049/jimmunol.200.supp.169.14
  • OpenAlex ID W2908843864
  • Type Conference-abstract
  • Language EN
  • Published 01 May 2018
  • Volume 200 (Supplement_1)
  • Pages 169.14
  • Source The Journal of Immunology
  • Publisher American Association of Immunologis…
  • Countries 1
  • Institutions 2
  • Added 25 Jan 2019
  • Updated 24 Sep 2026
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Defining how mitochondrial DNA stress regulates innate immune responses

Conference-abstract 2018 EN

Abstract Polymerase gamma (pol γ) is nuclear-encoded protein responsible for mtDNA replication. POLG mutations are recognized as a significant cause of primary mitochondrial diseases and are implicated in a range of disorders. Several mouse models of POLG-related disease have been reported, the most well studied is the POLG-mutator mouse. Animals homozygous for the mutant alleles exhibit elevated…

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3 authors
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1 Camila Guerra Martinez Texas A&M Health Science Cente… (US) Texas A&M University (US)
2 Yuanjiu Lei Texas A&M Health Science Cente… (US) Texas A&M University (US)
3 Phillip K. West Texas A&M Health Science Cente… (US) Texas A&M University (US)

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