Mitochondrial Coordination of Macrophage Metabolic and Inflammatory Programming During Bacterial Infection

Macrophages, ubiquitous and multifaceted innate immune cells, guide initiation and resolution of inflammation during bacterial infection. The capacity of macrophages to adapt to environmental cues depends on their remarkable metabolic plasticity. In this context, the mitochondrial network acts as a hub for energetics, metabolism, and signaling, but how it coordinates these functions in response to…