Type I interferon decreases macrophage energy metabolism dur…
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- DOI 10.1016/j.celrep.2021.109195
- PMID https://pubmed.ncbi.nlm.nih.gov/34077724
- PMCID https://www.ncbi.nlm.nih.gov/pmc/articles/8244443
- OpenAlex ID W3165160504
- Type Article
- Language EN
- Published 01 Jun 2021
- Volume 35 (9)
- Pages 109195
- Source Cell Reports
- Publisher Cell Press
- FWCI 6.89
- Countries 1
- Institutions 3
- Added 07 Jun 2021
- Updated 28 Oct 2026
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Type I interferon decreases macrophage energy metabolism during mycobacterial infection
Article 2021 EN Gold
Metabolic reprogramming powers and polarizes macrophage functions, but the nature and regulation of this response during infection with pathogens remain controversial. In this study, we characterize the metabolic and transcriptional responses of murine macrophages to Mycobacterium tuberculosis (Mtb) in order to disentangle the underlying mechanisms. We find that type I interferon (IFN) signaling c…
135
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93
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7
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6.89
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7 authors| # | Author | Institutions | ORCID |
|---|---|---|---|
| 1 | Gregory S. Olson | University of Washington (US) Seattle Children's Research In… (US) | |
| 2 | Tara A. Murray | Seattle Children's Research In… (US) | — |
| 3 | Ana N. Jahn | Seattle Children's Research In… (US) | |
| 4 | Dat Mai | Seattle Children's Research In… (US) | |
| 5 | Alan H. Diercks | Seattle Children's Research In… (US) | |
| 6 | Elizabeth S. Gold Corresponding | Virginia Mason Medical Center (US) Seattle Children's Research In… (US) | |
| 7 | Alan A. Aderem | University of Washington (US) Seattle Children's Research In… (US) |
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