Single-cell transcriptomic analysis of canine insulinoma rev…
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- DOI 10.1186/s44356-025-00026-3
- PMID https://pubmed.ncbi.nlm.nih.gov/40438247
- PMCID https://www.ncbi.nlm.nih.gov/pmc/articles/12106163
- OpenAlex ID W4410744905
- Type Article
- Language EN
- Published 26 May 2025
- Volume 2 (1)
- Pages 13
- Source Veterinary oncology.
- Publisher BioMed Central
- FWCI 1.32
- Countries 1
- Institutions 4
- Added 27 May 2025
- Updated 28 Oct 2026
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Single-cell transcriptomic analysis of canine insulinoma reveals distinct sub-populations of insulin-expressing cancer cells
Article 2025 EN Hybrid
Abstract Canine malignant insulinoma is a rare, highly metastatic and life-threatening neuroendocrine tumour of pancreatic beta cells. To map the single-cell transcriptomic landscape of canine insulinoma for the first time, transcriptomic profiles of 5,532 cells were captured from two spontaneous insulinomas (Patient 1 and 2) and one associated metastasis (Patient 2) in two Boxer dogs. Distinct ca…
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10
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10 authors| # | Author | Institutions | ORCID |
|---|---|---|---|
| 1 | Marsha D. Wallace | Royal Veterinary College (GB) University of Oxford (GB) | |
| 2 | MICHAEL E. HERRTAGE | University of Cambridge (GB) | — |
| 3 | Ruth Gostelow | Royal Veterinary College (GB) | |
| 4 | L. Owen | University of Cambridge (GB) | — |
| 5 | L. Rutherford | Royal Veterinary College (GB) | — |
| 6 | K. Hughes | University of Cambridge (GB) | — |
| 7 | Alice L. Denyer | Royal Veterinary College (GB) | |
| 8 | Briän Catchpole | Royal Veterinary College (GB) | — |
| 9 | Christopher A. O’Callaghan | Centre for Human Genetics (GB) University of Oxford (GB) | |
| 10 | Lucy J. Davison Corresponding | Royal Veterinary College (GB) University of Oxford (GB) |
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