Gene expression profiling of canine insulinomas and metastases

Insulinomas are pancreatic tumours that consist of modified and multiplying β-cells. Approximately 95% of the canine insulinomas are malignant. The question is what could make the primary insulinomas slow proliferating and well differentiated and the metastases fast growing and less differentiated. The gene expression of 10 primary insulinomas is compared to their accompanying metastases in MetaCo…