TENM4 is an essential transduction component for touch

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2024
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Work Details
  • DOI 10.1101/2024.10.10.617546
  • OpenAlex ID W4403361236
  • Type Preprint
  • Language EN
  • Published 12 Oct 2024
  • Source bioRxiv (Cold Spring Harbor Laboratory)
  • Publisher Cold Spring Harbor Laboratory
  • Countries 3
  • Institutions 6
  • Added 13 Oct 2024
  • Updated 27 Oct 2026
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TENM4 is an essential transduction component for touch

Preprint 2024 EN Green

SUMMARY Gentle touch is conveyed to the brain by fast-conducting sensory fibers. Mechanosensitive ion channels at the terminals of these neurons are thought to be gated by extracellular tethers that transmit force from the surrounding matrix to the channel complex, but the molecular identity of such tethers has remained unknown. Here, we identify Teneurin-4 (TENM4) as an essential extracellular li…

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20 authors
#AuthorInstitutionsORCID
1 Mohammed A. Khallaf Max Delbrück Center (DE) Assiut University (EG)
2 Angela Tzu-Lun Huang Max Delbrück Center (DE)
3 Letizia Dalmasso Max Delbrück Center (DE) —
4 Sampurna Chakrabarti Max Delbrück Center (DE)
5 Rowena Groeneveld Max Delbrück Center (DE)
6 Yinth Andrea Bernal Sierra Max Delbrück Center (DE)
7 Jonathan Alexis García-Contreras Max Delbrück Center (DE) —
8 Emilie Nello Max Delbrück Center (DE) —
9 Anja Schütz Max Delbrück Center (DE)
10 Valérie Bégay Max Delbrück Center (DE) Berlin Institute of Health at … (DE) +1
11 Alessandro Santuz Max Delbrück Center (DE)
12 Sarah Hedtrich University of British Columbia (CA) Max Delbrück Center (DE) +1
13 Wei Hong Zhong Max Delbrück Center (DE)
14 Christina Schiel Max Delbrück Center (DE) —
15 Steven J. Middleton Max Delbrück Center (DE) —
16 Oliver Popp Max Delbrück Center (DE) Berlin Institute of Health at … (DE)
17 Niccolò Zampieri Max Delbrück Center (DE)
18 Philipp Mertins Max Delbrück Center (DE) Berlin Institute of Health at … (DE)
19 Severine Kunz Max Delbrück Center (DE) —
20 Gary R. Lewin Corresponding Max Delbrück Center (DE) Deutsches Zentrum für Psychisc… (DE) +1
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