Zinc release from mitochondria contributes to MPP+-induced lysosomal disruption and neuronal death

Abstract Autophagy dysregulation and lysosomal dysfunction are critical in Parkinson’s disease. However, the cause and pathogenic signaling of the lysosomal functional deficiency is unknown. Here, we report on the role of zinc as a link between mitochondrial damage and lysosomal depletion. A mitochondrial toxin, 1-methyl-4 phenylpyridinium (MPP⁺), increased reactive oxygen species (ROS) and intrac…