Zinc‐Mediated Lysosomal Destabilization Links Mitochondrial …
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- DOI 10.1111/jnc.70363
- PMID https://pubmed.ncbi.nlm.nih.gov/41622607
- PMCID https://www.ncbi.nlm.nih.gov/pmc/articles/12862199
- OpenAlex ID W7127045901
- Type Article
- Language EN
- Published 01 Feb 2026
- Volume 170 (2)
- Pages e70363
- Source Journal of Neurochemistry
- Publisher Wiley
- FWCI 8.40
- Countries 1
- Institutions 1
- Added 03 Feb 2026
- Updated 31 Oct 2026
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Zinc‐Mediated Lysosomal Destabilization Links Mitochondrial Damage to Neuronal Death in a Cellular MPP + Model of Parkinson's Disease
Article 2026 EN Hybrid
ABSTRACT Dysregulation of autophagy and lysosomal function is central to Parkinson's disease (PD), yet the upstream mechanisms leading to lysosomal failure remain unclear. Across primary mouse cortical neurons, MT‐3 deficient primary mouse astrocytes, human iPSC‐derived midbrain dopaminergic neurons, and Rho 0 CHO cells lacking mitochondrial respiration, we investigated how mitochondrial stress pe…
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1 SDGsAuthors & Affiliations
6 authors| # | Author | Institutions | ORCID |
|---|---|---|---|
| 1 | Hyun‐Seung Lee | Sejong University (KR) | |
| 2 | Sun‐Ah Kang | Sejong University (KR) | — |
| 3 | Jae-Won Eom | Sejong University (KR) | |
| 4 | Min Seong Kim | Sejong University (KR) | — |
| 5 | Ji‐Soo Kim | Sejong University (KR) | — |
| 6 | Yang‐Hee Kim Corresponding | Sejong University (KR) | — |
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