Corticotropin-releasing hormone signaling from prefrontal cortex to lateral septum supports social novelty preference

Abstract Social preference, the decision to interact with one member of the same species over another, is a key feature of optimizing social interactions. In rodents, social preference relies on both extrinsic factors, such as sex, strain and kinship, and intrinsic ones, such as the memory of previous encounters, which favors interactions with novel compared to familiar animals (social novelty pre…