Fc receptor-like 5 and anti-CD20 treatment response in granu…

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Fc receptor-like 5 and anti-CD20 treatment response in granulomatosis with polyangiitis and microscopic polyangiitis

Article 2020 EN Gold

BACKGROUNDBaseline expression of FCRL5, a marker of naive and memory B cells, was shown to predict response to rituximab (RTX) in rheumatoid arthritis. This study investigated baseline expression of FCRL5 as a potential biomarker of clinical response to RTX in granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA).METHODSA previously validated quantitative PCR-based (qPCR-based)…

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18 authors
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1 Kasia M. Owczarczyk King's College London (GB)
2 Matthew D. Cascino Genentech —
3 Cecile T.J. Holweg Genentech
4 Gaik Wei Tew Genentech
5 Ward A. Ortmann Genentech
6 Timothy W. Behrens Genentech
7 Thomas Hellmut Schindler F. Hoffmann-La Roche AG (CH)
8 Carol A. Langford Cleveland Clinic (US)
9 E. William St. Clair Duke Medical Center (US)
10 Peter A. Merkel University of Pennsylvania (US)
11 Robert Spiera Hospital for Special Surgery (US)
12 Philip Seo Johns Hopkins University (US)
13 Cees G. M. Kallenberg University Medical Center Gron… (NL) —
14 Ulrich Specks Mayo Clinic (US)
15 Noha Lim Immune Tolerance Network (US)
16 John H. Stone Massachusetts General Hospital (US)
17 Paul G. Brunetta Genentech
18 Marco Prunotto Corresponding University of Geneva (CH) F. Hoffmann-La Roche AG (CH)
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