The Diverse Functions of Mutant 53, Its Family Members and I…
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- DOI 10.3390/ijms20246188
- PMID https://pubmed.ncbi.nlm.nih.gov/31817935
- OpenAlex ID W2994288809
- Type Article
- Language EN
- Published 07 Dec 2019
- Volume 20 (24)
- Pages 6188
- Source International Journal of Molecular Scien…
- Publisher Multidisciplinary Digital Publishin…
- FWCI 1.00
- Countries 1
- Institutions 1
- Added 10 Oct 2025
- Updated 21 Oct 2026
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The Diverse Functions of Mutant 53, Its Family Members and Isoforms in Cancer
Article 2019 EN Gold
The p53 family of proteins has grown substantially over the last 40 years. It started with p53, then p63, p73, isoforms and mutants of these proteins. The function of p53 as a tumour suppressor has been thoroughly investigated, but the functions of all isoforms and mutants and the interplay between them are still poorly understood. Mutant p53 proteins lose p53 function, display dominant-negative (…
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1 SDGsAuthors & Affiliations
2 authors| # | Author | Institutions | ORCID |
|---|---|---|---|
| 1 | Callum Hall | Cancer Research UK Manchester … (GB) | |
| 2 | Patricia A. J. Muller Corresponding | Cancer Research UK Manchester … (GB) |
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