Shiga Toxin Induces Lipid Compression: A Mechanism for Gener…

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Shiga Toxin Induces Lipid Compression: A Mechanism for Generating Membrane Curvature

Article 2019 EN Green

Biomembranes are hard to compress laterally, and membrane area compressibility has not been associated with biological processes. Using X-ray surface scattering, we observed that bacterial Shiga toxin compresses lipid packing in a gel phase monolayer upon binding to its cellular receptor, the glycolipid Gb3. This toxin-induced reorganization of lipid packing reached beyond the immediate membrane p…

30

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23

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6

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1.65

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6 authors
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1 Erik B. Watkins Corresponding Los Alamos National Laboratory (US)
2 Jaroslaw P. Majewski U.S. National Science Foundati… (US) Los Alamos National Laboratory (US) +2
3 Eva Y. Chi University of New Mexico (US)
4 Haifei Gao Centre National de la Recherch… (FR) Inserm (FR) +3 —
5 Jean‐Claude Florent Centre National de la Recherch… (FR) Inserm (FR) +3
6 Ludger Johannes Corresponding Centre National de la Recherch… (FR) Inserm (FR) +3

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