Endocytic Clathrin Coats Develop Curvature at Early Stages o…

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  • DOI 10.1101/715219
  • OpenAlex ID W2965322380
  • Type Preprint
  • Language EN
  • Published 26 Jul 2019
  • Source bioRxiv (Cold Spring Harbor Laboratory)
  • Publisher Cold Spring Harbor Laboratory
  • Countries 3
  • Institutions 14
  • Added 10 Oct 2025
  • Updated 16 Oct 2026
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Endocytic Clathrin Coats Develop Curvature at Early Stages of Their Formation

Preprint 2019 EN

Abstract Sculpting a flat patch of membrane into an endocytic vesicle requires curvature generation on the cell surface, which is the primary function of endocytic protein complexes. The mechanism through which membrane curvature is imposed during formation of clathrin-coated vesicles is an ongoing controversy. Using super-resolved live cell fluorescence imaging, we demonstrate that curvature gene…

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1 Nathan M. Willy The Ohio State University (US)
2 Joshua P. Ferguson The Ohio State University (US)
3 Salih Z. Silahli The Ohio State University (US) —
4 Cemal Cakez University of New Mexico (US) —
5 Farah Hasan The Ohio State University (US)
6 Yan Chen National University of Singapo… (SG)
7 Min Wu National University of Singapo… (SG) Mechanobiology Institute (SG)
8 Henry C. Chang Purdue University West Lafayet… (US)
9 Alex Travesset Iowa State University (US) Ames National Laboratory (US)
10 Siyu Li University of California, Rive… (US)
11 Roya Zandi University of California, Rive… (US)
12 Dong Li Chinese Academy of Sciences (CN) Institute of Biophysics (CN) +1
13 Eric Betzig Howard Hughes Medical Institut… (US) Janelia Research Campus (US) +1
14 Emanuele Cocucci The Ohio State University (US)
15 Cömert Kural Corresponding The Ohio State University (US)
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