The Effect of Hypoxia on Expression of HIF-2α and VEGF in BeWo Cell Line

Objective: To investigate the effect of hypoxia on the expression of VEGF in BeWo cells and the alteration of VEGF after down regulation of hypoxia- inducible factor 2α (HIF-2α). Methods: The BeWo cells were cultured under diff erent conditions and divided into four groups: normoxia group, hypoxia group, HI F-2α plus sense group, and HIF-2α antisense group. The mRNA level of HIF-2α a nd VEGF were…