Inhibitory effects of genistein on hypoxia-induced VEGF expression in ARPE-19 cells

Objective: To study the regulatory mechanism of genistein(Gen) in inhibiting hypoxia-induced vascular endothelial growth factor (VEGF) expression in ARPE-19 cells. Methods: Pretreated with different concentrations of Gen, ARPE-19 cells were exposed to hypoxia or normoxia conditions for 24 h ,then the expression of VEGF and c-fos,c-jun,HIF-1α,HIF-2α,HIF- 3αmRNA was detected by RT-PCR. Results: The…