Simvastatin rescues homocysteine-induced apoptosis of osteoc…
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- DOI 10.1507/endocrj.ej15-0480
- PMID https://pubmed.ncbi.nlm.nih.gov/26842590
- OpenAlex ID W2284503652
- Type Article
- Language EN
- Published 01 Jan 2016
- Volume 63 (4)
- Pages 389–395
- Source Endocrine Journal
- Publisher Japan Endocrine Society
- FWCI 1.39
- Countries 1
- Institutions 1
- Added 24 Jun 2016
- Updated 26 Sep 2026
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Simvastatin rescues homocysteine-induced apoptosis of osteocytic MLO-Y4 cells by decreasing the expressions of NADPH oxidase 1 and 2
Article 2016 EN Diamond
Clinical studies have shown that hyperhomocysteinemia is associated with bone fragility. Homocysteine (Hcy) induces apoptosis of osteoblastic cell lineage by increasing oxidative stress, which may contribute to Hcy-induced bone fragility. Statins, 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors, ameliorate oxidative stress by regulating oxidant and anti-oxidant enzymes. However, the eff…
17
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36
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6
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1.39
FWCI
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UN Sustainable Development Goals
1 SDGsAuthors & Affiliations
6 authors| # | Author | Institutions | ORCID |
|---|---|---|---|
| 1 | Ayumu Takeno | Shimane University (JP) | |
| 2 | Ippei Kanazawa | Shimane University (JP) | |
| 3 | Ken‐ichiro Tanaka | Shimane University (JP) | |
| 4 | Masakazu Notsu | Shimane University (JP) | |
| 5 | Maki Yokomoto‐Umakoshi | Shimane University (JP) | |
| 6 | Toshitsugu Sugimoto | Shimane University (JP) |
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