Simvastatin protects human osteosarcoma cells from oxidative…
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- DOI 10.3892/mmr.2011.641
- PMID https://pubmed.ncbi.nlm.nih.gov/22012179
- OpenAlex ID W2019000752
- Type Article
- Language EN
- Published 19 Oct 2011
- Volume 5 (2)
- Pages 483–8
- Source Molecular Medicine Reports
- Publisher Spandidos Publishing
- FWCI 0.52
- Countries 1
- Institutions 3
- Added 24 Jun 2016
- Updated 27 Oct 2026
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Simvastatin protects human osteosarcoma cells from oxidative stress-induced apoptosis through mitochondrial-mediated signaling
Article 2011 EN Bronze
Apoptosis of osteoblasts has been proposed as the common basis of osteoporosis, with oxidative stress as the major cause. This study was performed to investigate the protective effect of simvastatin (0.001-0.1 µM) on 100 µM hydrogen peroxide (H2O2)-mediated oxidative stress-induced apoptosis in human osteosarcoma (MG63) cells and the molecular mechanisms involved. Cell apoptosis was evaluated by o…
20
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28
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1
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0.52
FWCI
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1 SDGsAuthors & Affiliations
1 authors| # | Author | Institutions | ORCID |
|---|---|---|---|
| 1 | Yunmei Yang Corresponding | First Affiliated Hospital Zhej… (CN) State Key Laboratory of Diagno… (CN) +1 |
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