[Glucocorticoid and Bone. The inhibition of osteoblast differentiation and induction of osteocyte apoptosis through the regulation of Bcl-2 by glucocorticoids].

Glucocorticoid-induced osteoporosis is caused by the inhibition of osteoblast differentiation and induction of osteoblast and osteocyte apoptosis. Glucocorticoids inhibit osteoblast differentiation by reducing the expression of Wnt signaling proteins, osteocalcin, and AP-1. Further, glucocorticoids induce osteoblast and osteocyte apoptosis by regulating the expression of Bcl-2 family proteins. Apo…