An N-Ethyl-N-Nitrosourea Induced Corticotropin-Releasing Hor…
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- DOI 10.1210/en.2013-1247
- PMID https://pubmed.ncbi.nlm.nih.gov/24302625
- PMCID https://www.ncbi.nlm.nih.gov/pmc/articles/4192286
- OpenAlex ID W2137309558
- Type Article
- Language EN
- Published 04 Dec 2013
- Volume 155 (3)
- Pages 908–922
- Source Endocrinology
- Publisher Oxford University Press
- FWCI 1.31
- Countries 2
- Institutions 13
- Added 24 Jun 2016
- Updated 28 Oct 2026
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An N-Ethyl-N-Nitrosourea Induced Corticotropin-Releasing Hormone Promoter Mutation Provides a Mouse Model for Endogenous Glucocorticoid Excess
Article 2013 EN Hybrid
Cushing's syndrome, which is characterized by excessive circulating glucocorticoid concentrations, may be due to ACTH-dependent or -independent causes that include anterior pituitary and adrenal cortical tumors, respectively. ACTH secretion is stimulated by CRH, and we report a mouse model for Cushing's syndrome due to an N-ethyl-N-nitrosourea (ENU) induced Crh mutation at -120 bp of the promoter…
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16
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1.31
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16 authors| # | Author | Institutions | ORCID |
|---|---|---|---|
| 1 | Liz Bentley Corresponding | — | |
| 2 | Christopher T. Esapa | Churchill Hospital (GB) University of Oxford (GB) +1 | — |
| 3 | M. Andrew Nesbit | Churchill Hospital (GB) University of Oxford (GB) +1 | |
| 4 | Rosie A. Head | Churchill Hospital (GB) University of Oxford (GB) +1 | — |
| 5 | Holly Evans | University of Sheffield (GB) | |
| 6 | Darren Lath | University of Sheffield (GB) | |
| 7 | Cheryl L. Scudamore | Mary Lyon Centre at MRC Harwel… (GB) Medical Research Council (GB) | |
| 8 | Tertius Hough | Mary Lyon Centre at MRC Harwel… (GB) Medical Research Council (GB) | — |
| 9 | Christine Podrini | Wellcome Sanger Institute (GB) | |
| 10 | Fadil M. Hannan | Churchill Hospital (GB) University of Oxford (GB) +1 | |
| 11 | William Duncan Fraser | University of East Anglia (GB) Norwich Research Park (GB) | |
| 12 | Peter Ian Croucher | Garvan Institute of Medical Re… (AU) UNSW Sydney (AU) | |
| 13 | Matthew Arthur Brown | The University of Queensland (AU) Princess Alexandra Hospital (AU) | |
| 14 | Steve D. M. Brown | — | |
| 15 | Roger Cox | — | |
| 16 | Rajesh V. Thakker | Churchill Hospital (GB) University of Oxford (GB) +1 |
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