Induction of neutrophil responsiveness to myeloperoxidase an…

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Induction of neutrophil responsiveness to myeloperoxidase antibodies by their exposure to supernatant of degranulated autologous neutrophils

Article 2000 EN

Antibodies against myeloperoxidase (MPO) and proteinase 3 (PR3) are the predominant autoantibodies present in antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis. Their binding to the corresponding antigen on the surface of polymorphonuclear neutrophils (PMNs) is believed to trigger the disease process. Cytokines released during an inflammatory reaction are thought to prime resting PM…

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3 authors
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1 Christoph Hess University Hospital of Basel (CH)
2 Salima Sadallah University Hospital of Basel (CH) —
3 Jürg‐Alfred Schifferli University Hospital of Basel (CH) —

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