Human tumor necrosis factor mutants with preferential bindin…
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- DOI 10.1111/j.1432-1033.1994.tb18678.x
- PMID https://pubmed.ncbi.nlm.nih.gov/8143731
- OpenAlex ID W2135245094
- Type Article
- Language EN
- Published 01 Mar 1994
- Volume 220 (3)
- Pages 771–779
- Source European Journal of Biochemistry
- Publisher Wiley
- FWCI 1.41
- Countries 1
- Institutions 2
- Added 10 Oct 2025
- Updated 14 Oct 2026
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Human tumor necrosis factor mutants with preferential binding to and activity on either the R55 or R75 receptor
Article 1994 EN
Previously, we reported that the cytotoxic activity of human (h) tumor necrosis factor (TNF) on murine (m) L929 cells requires the integrity of three loops (positions 30-36, 84-88 and 138-150) which cluster around the interface between each two subunits of the trimeric hTNF structure. The collection of hTNF mutants was further characterized by their activity on various human cell systems as well a…
51
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4
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1.41
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UN Sustainable Development Goals
1 SDGsAuthors & Affiliations
4 authors| # | Author | Institutions | ORCID |
|---|---|---|---|
| 1 | Xaveer Van Ostade | Ghent University (BE) | |
| 2 | Peter Vandenabeele | Ghent University (BE) | |
| 3 | Jan H. Tavernier | Roche (Belgium) (BE) | |
| 4 | Walter C. Fiers Corresponding | Ghent University (BE) | — |
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