Homocysteine Suppresses the Expression of the Collagen Cross…
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- DOI 10.1074/jbc.m110.166181
- PMID https://pubmed.ncbi.nlm.nih.gov/21148317
- PMCID https://www.ncbi.nlm.nih.gov/pmc/articles/3037671
- OpenAlex ID W2072603086
- Type Article
- Language EN
- Published 10 Dec 2010
- Volume 286 (7)
- Pages 5578–5588
- Source Journal of Biological Chemistry
- Publisher Elsevier BV
- FWCI 4.24
- Countries 1
- Institutions 3
- Added 24 Jun 2016
- Updated 28 Oct 2026
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Homocysteine Suppresses the Expression of the Collagen Cross-linker Lysyl Oxidase Involving IL-6, Fli1, and Epigenetic DNA Methylation
Article 2010 EN Hybrid
Elevated homocysteine (Hcys) serum levels represent a risk factor for several chronic pathologies, including cardiovascular disease, atherosclerosis, and chronic renal failure, and affect bone development, quality, and homeostasis. Hcys influences the formation of a stable bone matrix directly through the inhibition of the collagen cross-linking enzyme lysyl oxidase (Lox) and, as we have shown rec…
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1 SDGsAuthors & Affiliations
7 authors| # | Author | Institutions | ORCID |
|---|---|---|---|
| 1 | Roman Thaler | Hanusch Hospital (AT) Ludwig Boltzmann Institute of … (AT) | |
| 2 | M. Agsten | Hanusch Hospital (AT) Ludwig Boltzmann Institute of … (AT) | — |
| 3 | Silvia G. Spitzer | Hanusch Hospital (AT) Ludwig Boltzmann Institute of … (AT) | |
| 4 | Eleftherios P. Paschalis | Hanusch Hospital (AT) Ludwig Boltzmann Institute of … (AT) | |
| 5 | Heidrun Karlic | Hanusch Hospital (AT) Ludwig Boltzmann Institute for… (AT) | |
| 6 | Klaus Klaushofer A | Hanusch Hospital (AT) Ludwig Boltzmann Institute of … (AT) | — |
| 7 | Franz Varga Corresponding | Hanusch Hospital (AT) Ludwig Boltzmann Institute of … (AT) | — |
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