17β‐Estradiol activates ICI 182,780‐sensitive estrogen recep…

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17β‐Estradiol activates ICI 182,780‐sensitive estrogen receptors and cyclic GMP‐dependent thioredoxin expression for neuroprotection

Article 2003 EN

Clinical studies suggest that estrogen may improve cognition in Alzheimer's patients. Basic experiments demonstrate that 17beta-estradiol protects against neurodegeneration in both cell and animal models. In the present study, a human SH-SY5Y cell model was used to investigate molecular mechanisms underlying the receptor-mediated neuroprotection of physiological concentrations of 17beta-estradiol.…

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1 Sang Yong Lee Pennsylvania State University (US) Penn State Milton S. Hershey M… (US)
2 Tsugunobu Andoh University of Toyama (JP)
3 Dennis L. Murphy National Institutes of Health (US) National Institute of Mental H… (US) —
4 Chuang C. Chiueh National Institutes of Health (US) National Institute of Mental H… (US) —

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