Human recombinant erythropoietin alters the flow-dependent v…

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  • DOI 10.1139/y11-032
  • PMID https://pubmed.ncbi.nlm.nih.gov/21777087
  • OpenAlex ID W2007117009
  • Type Article
  • Language EN
  • Published 01 Jun 2011
  • Volume 89 (6)
  • Pages 435–443
  • Source Canadian Journal of Physiology and Pharm…
  • Publisher NRC Research Press
  • FWCI 0.44
  • Countries 1
  • Institutions 2
  • Added 24 Jun 2016
  • Updated 25 Oct 2026
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Human recombinant erythropoietin alters the flow-dependent vasodilatation of in vitro perfused rat mesenteric arteries with unbalanced endothelial endothelin-1 / nitric oxide ratio

Article 2011 EN

Chronic use of human recombinant erythropoietin (r-HuEPO) is accompanied by serious vascular side effects related to the rise in blood viscosity and shear stress. We investigated the direct effects of r-HuEPO on endothelium and nitric oxide (NO)-dependent vasodilatation induced by shear stress of cannulated and pressurized rat mesenteric resistance arteries. Intravascular flow was increased in the…

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4 authors
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1 Tlili Barhoumi Université d'Avignon et des Pa… (FR)
2 Isabelle Jallat Université de Franche-Comté (FR) —
3 Alain Berthelot Université de Franche-Comté (FR) —
4 Pascal Laurant Université d'Avignon et des Pa… (FR) —
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