3.6 kb of the 5′ Flanking DNA Activates the Mouse Tyrosine Hydroxylase Gene Promoter Without Catecholaminergic‐Specific Expression

The tyrosine hydroxylase (TH) gene is expressed exclusively in cells and neurons that synthesize and release L-DOPA or catecholamines. To further understand the molecular genetic mechanisms that regulate this cell-type specific expression, a chimeric gene was prepared by linking 3.6 kb of the 5' flanking DNA of the mouse TH gene, including the +1 initiation site for transcription, to an E. coli be…