Mechanisms of Whole Blood-induced Cerebral Arterial Contract…

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Mechanisms of Whole Blood-induced Cerebral Arterial Contraction

Article 1981 EN

Using rabbit cerebral arteries in an in vitro chamber, we examined the cerebral arterial contraction initiated by clotting whole blood. By using methysergide maleate and a novel thromboxane synthetase inhibitor, 1-carboxyheptylimidazole (1-CHI), we studied the contributions of both serotonin and the prostaglandin metabolite thromboxane A2. Nontreated platelet-rich plasma (PRP) in the presence of m…

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1 Mark A. Schumacher University of California San D… (US) University of California San D… (US)
2 John F. Alksne University of California San D… (US) University of California San D… (US) —

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