Hypermutation in derepressed operons of Escherichia coli K12
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- DOI 10.1073/pnas.96.9.5089
- PMID https://pubmed.ncbi.nlm.nih.gov/10220423
- OpenAlex ID W1969080789
- Type Article
- Language EN
- Published 27 Apr 1999
- Volume 96 (9)
- Pages 5089–5094
- Source Proceedings of the National Academy of S…
- Publisher National Academy of Sciences
- FWCI 2.90
- Countries 1
- Institutions 1
- Added 24 Jun 2016
- Updated 25 Sep 2026
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Hypermutation in derepressed operons of Escherichia coli K12
Article 1999 EN Green
This article presents evidence that starvation for leucine in an Escherichia coli auxotroph triggers metabolic activities that specifically target the leu operon for derepression, increased rates of transcription, and mutation. Derepression of the leu operon was a prerequisite for its activation by the signal nucleotide, guanosine tetraphosphate, which accumulates in response to nutritional stress…
73
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60
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3
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2.90
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3 authors| # | Author | Institutions | ORCID |
|---|---|---|---|
| 1 | Barbara E. Wright | University of Montana (US) | — |
| 2 | Angelika Longacre | University of Montana (US) | — |
| 3 | Jacqueline M. Reimers | University of Montana (US) | — |
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