AN IMPAIRED DNAM-1/NKP80 NK-CELL ACTIVATION AND T-CELL EXHAUSTION PROFILE AT DIAGNOSIS PRECEDE SUBOPTIMAL EARLY MOLECULAR RESPONSE IN CML

In Chronic Myeloid Leukemia (CML), early risk assessment traditionally relies on clinical scoring systems such as Sokal and ELTS, which do not capture host immune surveillance, a potential determinant of tyrosine kinase inhibitor (TKI) efficacy. Early identification of patients unlikely to achieve optimal molecular response may be particularly relevant when rapid disease control is clinically desi…