THE MPN MICROENVIRONMENT DRIVES NK-CELL MATURATION DEFECTS A…
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- DOI 10.1016/j.htct.2026.107540
- OpenAlex ID W7223086510
- Type Article
- Language EN
- Published 01 Oct 2026
- Volume 48
- Pages 107540
- Source Hematology Transfusion and Cell Therapy
- Publisher Elsevier BV
- Countries 2
- Institutions 2
- Added 22 Oct 2026
- Updated 26 Oct 2026
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THE MPN MICROENVIRONMENT DRIVES NK-CELL MATURATION DEFECTS ASSOCIATED WITH HIGH-RISK DISEASE
Article 2026 EN Diamond
Myelofibrosis (MF) is characterized by chronic inflammation, progressive bone marrow fibrosis, and impaired immune surveillance. Although natural killer (NK) cell dysfunction has been described in myeloproliferative neoplasms (MPN), its relationship with MF severity and the contribution of the malignant microenvironment remain poorly defined. We hypothesized that progressive MF induces an NK-cell…
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UN Sustainable Development Goals
1 SDGsAuthors & Affiliations
18 authors| # | Author | Institutions | ORCID |
|---|---|---|---|
| 1 | Mariana Mariana MEDEIROS | Universidade de São Paulo (BR) | — |
| 2 | Allana CARVALHO | Universidade de São Paulo (BR) | — |
| 3 | Alban Johansson | QIMR Berghofer Medical Researc… (AU) | |
| 4 | Larissa Sarri Binelli | Universidade de São Paulo (BR) | — |
| 5 | Camila Araújo Bernardino GARCIA | Universidade de São Paulo (BR) | — |
| 6 | Isabela Lefol Arruda | Universidade de São Paulo (BR) | |
| 7 | Beatriz ADJAFRE | Universidade de São Paulo (BR) | — |
| 8 | Leticia MARANI | Universidade de São Paulo (BR) | — |
| 9 | Priscila Santos Scheucher | Universidade de São Paulo (BR) | |
| 10 | Josiane Lilian dos Santos Schiavinato | Universidade de São Paulo (BR) | — |
| 11 | Cleide L. Araujo | Universidade de São Paulo (BR) | — |
| 12 | Emily Cooper | QIMR Berghofer Medical Researc… (AU) | — |
| 13 | Natalie Chan | QIMR Berghofer Medical Researc… (AU) | — |
| 14 | Rafael PACCA | Universidade de São Paulo (BR) | — |
| 15 | Leonardo De Palma | Universidade de São Paulo (BR) | — |
| 16 | Megan BYWATER | QIMR Berghofer Medical Researc… (AU) | — |
| 17 | Steven Lane | QIMR Berghofer Medical Researc… (AU) | |
| 18 | Lorena Lobo de Figueiredo‐Pontes | Universidade de São Paulo (BR) |
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