The Half of Everything: Glucose Imbalance Hazards and Brain Vulnerability at the Extremes of Life

Glucose is more than an energetic substrate: its homeostasis emerges from continuous interactions between peripheral glucose-regulatory organs and the brain, where glucose availability, sensing, and utilization must be dynamically matched to metabolic demands. This narrative review examines how disruption of this balance may intersect with oxidative stress, inflammation, and brain vulnerability at…