A dual edge-activation strategy for rhein bilosomes enhances…
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- DOI 10.3389/fphar.2026.1798385
- PMID https://pubmed.ncbi.nlm.nih.gov/42266368
- PMCID https://www.ncbi.nlm.nih.gov/pmc/articles/13243890
- OpenAlex ID W7161830084
- Type Article
- Language EN
- Published 20 May 2026
- Volume 17
- Pages 1798385
- Source Frontiers in Pharmacology
- Publisher Frontiers Media
- Countries 3
- Institutions 4
- Added 21 May 2026
- Updated 28 Oct 2026
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A dual edge-activation strategy for rhein bilosomes enhances intradermal delivery and anti-melanoma efficacy
Article 2026 EN Gold
Introduction: The therapeutic potential of rhein (RH) in topical melanoma management is constrained by its poor aqueous solubility and limited intradermal bioavailability. This study proposes an innovative mechanism-driven formulation strategy to address these limitations and improve the therapeutic performance of RH against melanoma. Methods: A rhein-phospholipid complex (RH-PLC) was first prepar…
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UN Sustainable Development Goals
1 SDGsAuthors & Affiliations
6 authors| # | Author | Institutions | ORCID |
|---|---|---|---|
| 1 | Mahmoud Ismail Corresponding | Alexandria University (EG) | |
| 2 | Rasha Mahmoud Elkanayati Corresponding | University of Mississippi (US) | |
| 3 | Marwa Morsy Essawy | Alexandria University (EG) | |
| 4 | Eslam Elhanafy | University of Mississippi (US) Zewail City of Science and Tec… (EG) | |
| 5 | Ossama Y. Abdallah | Alexandria University (EG) | |
| 6 | Yosra S.R. Elnaggar Corresponding | Imam Abdulrahman Bin Faisal Un… (SA) |
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