Beneficial effects of the AT 2 receptor agonist buloxibutid …
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- DOI 10.1183/23120541.00249-2025
- PMID https://pubmed.ncbi.nlm.nih.gov/42440724
- OpenAlex ID W7125414319
- Type Article
- Language EN
- Published 22 Jan 2026
- Volume 12 (4)
- Pages 00249–2025
- Source ERJ Open Research
- Publisher European Respiratory Society
- Countries 2
- Institutions 4
- Added 23 Jan 2026
- Updated 29 Sep 2026
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Beneficial effects of the AT 2 receptor agonist buloxibutid (C21) against acute alveolar epithelial cell inflammation during antiviral responses
Article 2026 EN Gold
Aim Activation of the angiotensin II type 2 receptor (AT 2 receptor; encoded by AGTR2 ) has been shown to be beneficial during tissue injury and repair. Therefore, we aimed to investigate the expression of AT 2 receptor in human alveolar type II (ATII) cells, a cell population responsible for lung repair and regeneration, and the effect of the AT 2 receptor agonist buloxibutid (also known as C21),…
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UN Sustainable Development Goals
1 SDGsAuthors & Affiliations
11 authors| # | Author | Institutions | ORCID |
|---|---|---|---|
| 1 | Franco Conforti | University Hospital Southampto… (GB) NIHR Southampton Biomedical Re… (GB) +1 | |
| 2 | Joseph Bell | University Hospital Southampto… (GB) NIHR Southampton Biomedical Re… (GB) +1 | — |
| 3 | Robert A. Ridley | University Hospital Southampto… (GB) NIHR Southampton Biomedical Re… (GB) +1 | |
| 4 | Lareb S. N. Dean | University Hospital Southampto… (GB) NIHR Southampton Biomedical Re… (GB) +1 | |
| 5 | Matthew Loxham | University Hospital Southampto… (GB) NIHR Southampton Biomedical Re… (GB) +1 | |
| 6 | James Parkin | University Hospital Southampto… (GB) NIHR Southampton Biomedical Re… (GB) +1 | — |
| 7 | Aiman Alzetani | University Hospital Southampto… (GB) NIHR Southampton Biomedical Re… (GB) +1 | |
| 8 | Mark G. Jones | University Hospital Southampto… (GB) NIHR Southampton Biomedical Re… (GB) +1 | |
| 9 | C.‐J. Dalsgaard | Vicore Pharma (Sweden) (SE) | — |
| 10 | Johan Raud | Vicore Pharma (Sweden) (SE) | |
| 11 | Donna E. Davies | University Hospital Southampto… (GB) NIHR Southampton Biomedical Re… (GB) +1 |
Data: OpenAlex