Immune history confers antibody- and T cell-dependent cross-…

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Immune history confers antibody- and T cell-dependent cross-protection against highly pathogenic avian influenza H5N1 viruses

Article 2026 EN Diamond

The outbreak of highly pathogenic avian H5 influenza (HPAI) clade 2.3.4.4b in cattle has spread across the United States. Mice with pre-existing immunity to H1N1 virus or with a live-attenuated influenza vaccine showed protection against a lethal bovine-derived HPAI H5N1 viral challenge. Notably, ferrets with mixed immunity also demonstrated protection against a feline-derived H5N1 virus, independ…

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18 authors
#AuthorInstitutionsORCID
1 Pamela H. Brigleb St. Jude Children's Research H… (US)
2 Bridgett Sharp St. Jude Children's Research H… (US)
3 Lauren Lazure St. Jude Children's Research H… (US)
4 Brandi Livingston St. Jude Children's Research H… (US) —
5 Shelby Patrick St. Jude Children's Research H… (US) —
6 Victoria Meliopoulos St. Jude Children's Research H… (US)
7 Ericka Kirkpatrick Roubidoux St. Jude Children's Research H… (US)
8 Lee-Ann Van de Velde St. Jude Children's Research H… (US)
9 Shaoyuan Tan St. Jude Children's Research H… (US)
10 Dorothea R. Morris St. Jude Children's Research H… (US)
11 Tyler J. Ripperger St. Jude Children's Research H… (US)
12 Lauren Rowland St. Jude Children's Research H… (US)
13 Alexis C. Thompson Texas A&M University (US)
14 Katie E. Kleinhenz Texas A&M University (US) —
15 Velmurugan Balaraman St. Jude Children's Research H… (US)
16 Kiril M. Dimitrov Texas A&M University (US)
17 Paul G. Thomas St. Jude Children's Research H… (US)
18 Stacey Schultz‐Cherry Corresponding St. Jude Children's Research H… (US)

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