The role of the medial prefrontal cortex (cingulate gyrus) in the regulation of hypothalamo-pituitary-adrenal responses to stress

In the studies reported here we have examined the role of the medial prefrontal cortex (MpFC) in regulating hypothalamic-pituitary-adrenal (HPA) activity under basal and stressful conditions. In preliminary studies we characterized corticosteroid receptor binding in the rat MpFC. The results revealed high-affinity (K,,- 1 nM) binding with a moderate capacity (42.9 +- 3 fmol/mg) for 3H-aldosterone…