HIF-1α, HIF-2α and VHL mRNA expression in different cell lines under hypoxia

Hypoxia inducible factor-1a (HIF-1a) mRNA expression is significantly decreased under hypoxia in different cell lines exposed directly to hypoxia or treated with dimethyloxalylglycine which mimics hypoxic effects under normoxic conditions. However, the decreased expression of HIF-1a mRNA is accompanied by an increase of HIF-1a protein (pHIF-1a) level as well as by overexpression of known HIF-depen…