HnRNPA2B1 tunes antimycobacterial immune responses in macrophages through alternative splicing of Irgm1

ABSTRACT Onset and progression of active tuberculosis disease result from upsetting the delicate balance between Mtb virulence and host defenses. Because it dynamically tunes the functional output of protein expression in cells, alternative splicing, a process by which different mRNAs can be gen-erated from a single gene, is positioned to play a critical role in maintaining an equilibrated Mtb-mac…