Early Higher Plasma Regorafenib Concentration Predicts Short…

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  • DOI 10.1111/cts.70386
  • PMID https://pubmed.ncbi.nlm.nih.gov/41189363
  • OpenAlex ID W4415905267
  • Type Article
  • Language EN
  • Published 01 Nov 2025
  • Volume 18 (11)
  • Pages e70386
  • Source Clinical and Translational Science
  • Publisher Wiley
  • FWCI 0.37
  • Countries 1
  • Institutions 4
  • Added 05 Nov 2025
  • Updated 29 Sep 2026
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Early Higher Plasma Regorafenib Concentration Predicts Shorter PFS in Japanese Patients With mCRC

Article 2025 EN Gold

The pharmacokinetics of regorafenib and its active metabolites, M2 and M5, vary widely among individual patients. However, the relationship between these plasma concentrations and therapeutic efficacy remains unclear. Patients with metastatic colorectal cancer (mCRC) receiving regorafenib as third-line or later treatment were enrolled. The initial dose was 120 mg daily for 1 week, then adjusted ba…

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0.37

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20 authors
#AuthorInstitutionsORCID
1 Kazuo Kobayashi The Cancer Institute Hospital (JP) Japanese Foundation For Cancer… (JP)
2 Takeru Wakatsuki Corresponding The Cancer Institute Hospital (JP) Japanese Foundation For Cancer… (JP)
3 Erika Sugiyama SHOWA Medical University (JP)
4 Eiji Shinozaki The Cancer Institute Hospital (JP) Japanese Foundation For Cancer… (JP)
5 Masataka Tajima SHOWA Medical University (JP)
6 Mariko Ogura The Cancer Institute Hospital (JP) Japanese Foundation For Cancer… (JP)
7 Keisho Chìn The Cancer Institute Hospital (JP) Japanese Foundation For Cancer… (JP)
8 Akira Ooki The Cancer Institute Hospital (JP) Japanese Foundation For Cancer… (JP)
9 Hiroki Osumi The Cancer Institute Hospital (JP) Japanese Foundation For Cancer… (JP)
10 Shota Fukuoka The Cancer Institute Hospital (JP) Japanese Foundation For Cancer… (JP)
11 Shohei Udagawa The Cancer Institute Hospital (JP) Japanese Foundation For Cancer… (JP)
12 Keitaro Shimozaki The Cancer Institute Hospital (JP) Japanese Foundation For Cancer… (JP)
13 Takeshi Aoyama The Cancer Institute Hospital (JP) Japanese Foundation For Cancer… (JP)
14 Yasuhiro Nakano The Cancer Institute Hospital (JP) Japanese Foundation For Cancer… (JP) —
15 Kazuyoshi Kawakami The Cancer Institute Hospital (JP) Japanese Foundation For Cancer… (JP)
16 Wataru Suzuki The Cancer Institute Hospital (JP) Japanese Foundation For Cancer… (JP)
17 Takashi Yokokawa Tokyo University of Pharmacy a… (JP) The Cancer Institute Hospital (JP) +1
18 Hitoshi Sato SHOWA Medical University (JP)
19 Masakazu Yamaguchi The Cancer Institute Hospital (JP) Japanese Foundation For Cancer… (JP)
20 Kensei Yamaguchi The Cancer Institute Hospital (JP) Japanese Foundation For Cancer… (JP)

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